Motif ID: MEF2{A,B,C,D}.p2

Z-value: 2.334


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Cchr5_-_881553600.572.1e-02Click!
LOC729991-MEF2Bchr19_-_191639160.224.0e-01Click!
MEF2Achr15_+_979237370.224.1e-01Click!
MEF2Bchr19_-_19142053-0.184.9e-01Click!
MEF2Dchr1_-_1547371620.097.3e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_210876560 7.193 NM_079422
 MYL1
myosin, light chain 1, alkali; skeletal, fast
chrX_-_21686079 6.184 NM_014332
 SMPX
small muscle protein, X-linked
chr17_-_10500189 5.284 NM_002470
 MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr10_-_75085754 5.158 NM_001114133
 SYNPO2L
synaptopodin 2-like
chr1_-_116112684 5.143 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116112853 5.139 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116112921 4.892 NM_001232
 CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_190635566 4.849 NM_005259
 MSTN
myostatin
chr2_+_170074457 4.167 NM_006063
 KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr10_-_75080784 3.958 NM_024875
 SYNPO2L
synaptopodin 2-like
chr12_+_79625538 3.929 NM_002469
 MYF6
myogenic factor 6 (herculin)
chr1_-_199657468 3.898 NM_003281
 TNNI1
troponin I type 1 (skeletal, slow)
chr1_-_199613427 3.770 NM_000364
NM_001001430
NM_001001431
NM_001001432
 TNNT2



troponin T type 2 (cardiac)



chr1_-_199613406 3.767 TNNT2
troponin T type 2 (cardiac)
chr5_+_53787187 3.443 NM_006308
 HSPB3
heat shock 27kDa protein 3
chr1_-_151784889 3.106 NM_002961
NM_019554
 S100A4

S100 calcium binding protein A4

chr17_-_10265991 2.968 NM_002472
 MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr20_+_9236446 2.801 NM_000933
 PLCB4
phospholipase C, beta 4
chr5_+_155686333 2.692 NM_000337
NM_001128209
NM_172244
 SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr7_+_93862137 2.665 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
6.44 4.09e-06 GO:0030049 muscle filament sliding
6.44 4.09e-06 GO:0033275 actin-myosin filament sliding
6.27 6.37e-06 GO:0070252 actin-mediated cell contraction
5.73 2.53e-04 GO:0006941 striated muscle contraction
4.98 8.88e-05 GO:0030048 actin filament-based movement
3.12 6.74e-06 GO:0003012 muscle system process
2.89 5.74e-04 GO:0006936 muscle contraction
2.81 6.52e-04 GO:0007517 muscle organ development
2.53 2.56e-04 GO:0061061 muscle structure development
2.40 1.04e-03 GO:0030029 actin filament-based process

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
12.70 2.31e-02 GO:0031430 M band
11.34 5.73e-03 GO:0005861 troponin complex
7.94 1.26e-02 GO:0031672 A band
5.54 6.63e-13 GO:0030017 sarcomere
5.34 1.09e-14 GO:0030016 myofibril
5.19 2.41e-13 GO:0044449 contractile fiber part
5.03 2.25e-04 GO:0031674 I band
5.01 1.11e-13 GO:0043292 contractile fiber
4.96 5.09e-03 GO:0030018 Z disc
3.32 1.77e-02 GO:0042383 sarcolemma
2.02 2.43e-02 GO:0015629 actin cytoskeleton
1.46 7.94e-03 GO:0005856 cytoskeleton
1.32 6.76e-03 GO:0043228 non-membrane-bounded organelle
1.32 6.76e-03 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
4.65 2.37e-03 GO:0008307 structural constituent of muscle
1.99 4.26e-02 GO:0003779 actin binding