Motif ID: MEF2{A,B,C,D}.p2

Z-value: 2.334


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Cchr5_-_881553600.572.1e-02Click!
LOC729991-MEF2Bchr19_-_191639160.224.0e-01Click!
MEF2Achr15_+_979237370.224.1e-01Click!
MEF2Bchr19_-_19142053-0.184.9e-01Click!
MEF2Dchr1_-_1547371620.097.3e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_210876560 7.193 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chrX_-_21686079 6.184 NM_014332
SMPX
small muscle protein, X-linked
chr17_-_10500189 5.284 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr10_-_75085754 5.158 NM_001114133
SYNPO2L
synaptopodin 2-like
chr1_-_116112684 5.143 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116112853 5.139 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116112921 4.892 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_190635566 4.849 NM_005259
MSTN
myostatin
chr2_+_170074457 4.167 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr10_-_75080784 3.958 NM_024875
SYNPO2L
synaptopodin 2-like
chr12_+_79625538 3.929 NM_002469
MYF6
myogenic factor 6 (herculin)
chr1_-_199657468 3.898 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr1_-_199613427 3.770 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr1_-_199613406 3.767 TNNT2
troponin T type 2 (cardiac)
chr5_+_53787187 3.443 NM_006308
HSPB3
heat shock 27kDa protein 3
chr1_-_151784889 3.106 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr17_-_10265991 2.968 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr20_+_9236446 2.801 NM_000933
PLCB4
phospholipase C, beta 4
chr5_+_155686333 2.692 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr7_+_93862137 2.665 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr6_-_169395847 2.654 THBS2
thrombospondin 2
chr12_-_109842736 2.628 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr5_-_83052606 2.608 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr6_-_169395972 2.575 NM_003247
THBS2
thrombospondin 2
chr2_-_210888010 2.556 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr17_+_42641712 2.494 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr14_-_103058568 2.486 CKB
creatine kinase, brain
chr12_+_118100977 2.302 NM_014365
HSPB8
heat shock 22kDa protein 8
chr3_+_139550368 2.213 MRAS
muscle RAS oncogene homolog
chr3_+_8750485 2.153 NM_033337
NM_001234
CAV3

caveolin 3

chrX_+_70438352 2.129 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr3_+_35696119 2.066 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr14_-_103058865 2.011 NM_001823
CKB
creatine kinase, brain
chr21_+_29439768 1.922 C21orf7
chromosome 21 open reading frame 7
chr8_-_122722674 1.916 NM_005328
HAS2
hyaluronan synthase 2
chr5_-_42847716 1.794 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr10_+_91142301 1.789 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr2_+_233206450 1.757 NM_025202
EFHD1
EF-hand domain family, member D1
chr9_+_138991775 1.706 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr4_+_41057507 1.609 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chrX_-_11194015 1.609 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chrX_+_152699616 1.597 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr17_-_10362583 1.562 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr17_+_42641426 1.558 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr2_+_233206181 1.554 EFHD1
EF-hand domain family, member D1
chr17_+_1612056 1.535 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr13_-_35327798 1.495 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr7_-_143213296 1.494 FAM115A
family with sequence similarity 115, member A
chr2_-_162808123 1.466 NM_004460
FAP
fibroblast activation protein, alpha
chr4_+_169654742 1.367 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr17_+_1612031 1.359 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr4_+_120276386 1.358 NM_016599
MYOZ2
myozenin 2
chr9_+_96561750 1.348 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr4_-_5881271 1.340 CRMP1
collapsin response mediator protein 1
chr1_+_78243181 1.330 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr17_+_1611983 1.316 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr4_-_186934059 1.305 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr1_-_31618405 1.296 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr11_+_1816808 1.258 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr10_+_88418147 1.255 NM_001171610
LDB3
LIM domain binding 3
chr3_-_115825742 1.244 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr21_+_25933459 1.240 NM_021219
JAM2
junctional adhesion molecule 2
chrX_-_138114846 1.206 NM_001139498
NM_001139500
NM_001139501
FGF13


fibroblast growth factor 13


chr17_+_1612092 1.164 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_88418243 1.126 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr3_+_8518539 1.115 LMCD1
LIM and cysteine-rich domains 1
chr11_+_1897374 1.090 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr3_+_139550134 1.076 NM_001085049
MRAS
muscle RAS oncogene homolog
chr11_+_130745580 1.070 NM_001048209
NTM
neurotrimin
chr1_+_144236346 1.067 NM_003637
ITGA10
integrin, alpha 10
chr9_+_99303639 1.061 NM_003275
TMOD1
tropomodulin 1
chr13_+_75232797 1.059 NM_015842
LMO7
LIM domain 7
chr4_-_143987053 0.990 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr3_+_8518508 0.940 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr6_-_26232109 0.932 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr19_-_50514681 0.923 CKM
creatine kinase, muscle
chr8_+_1980564 0.921 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr1_+_149299530 0.908 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299504 0.900 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_109131814 0.882 RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_-_202595666 0.882 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr11_+_1817294 0.879 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr1_+_149299307 0.877 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299490 0.871 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_158352143 0.868 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr12_-_16652202 0.866 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_-_189752575 0.864 NM_000393
COL5A2
collagen, type V, alpha 2
chr9_+_99303282 0.864 NM_001166116
TMOD1
tropomodulin 1
chr6_-_24985432 0.863 NM_015864
FAM65B
family with sequence similarity 65, member B
chr4_-_187114407 0.824 SORBS2
sorbin and SH3 domain containing 2
chr17_-_3546108 0.808 P2RX5-TAX1BP3
P2RX5
P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5
chr13_-_33148899 0.803 STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_201202956 0.789 NM_016243
CYB5R1
cytochrome b5 reductase 1
chr5_-_150501393 0.776 NM_001193544
ANXA6
annexin A6
chr6_+_12825022 0.760 PHACTR1
phosphatase and actin regulator 1
chr10_-_73953699 0.716 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr19_+_3884100 0.707 NM_170678
ITGB1BP3
integrin beta 1 binding protein 3
chr19_-_20399601 0.700 ZNF826P
zinc finger protein 826, pseudogene
chr7_+_154943466 0.700 NM_001427
EN2
engrailed homeobox 2
chr16_-_31347151 0.694 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr2_+_219991342 0.693 NM_001927
DES
desmin
chr15_-_23204887 0.689 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr1_+_25629968 0.687 NM_018202
TMEM57
transmembrane protein 57
chr8_+_70541412 0.679 NM_001128204
NM_015170
SULF1

sulfatase 1

chr10_-_62373828 0.679 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr1_-_56817717 0.677 PPAP2B
phosphatidic acid phosphatase type 2B
chr8_-_49996353 0.665 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr9_+_123088217 0.659 GSN
gelsolin
chr18_-_3209986 0.651 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr18_+_9698299 0.650 RAB31
RAB31, member RAS oncogene family
chr6_+_131508153 0.634 NM_016377
AKAP7
A kinase (PRKA) anchor protein 7
chr1_+_144149794 0.624 NM_006472
TXNIP
thioredoxin interacting protein
chr10_+_5478521 0.617 NM_005863
NET1
neuroepithelial cell transforming 1
chr22_-_28972683 0.605 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr6_+_26232351 0.602 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr12_-_16650697 0.600 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_+_60016826 0.599 NM_001164470
NM_017716
MS4A12

membrane-spanning 4-domains, subfamily A, member 12

chr7_-_63660766 0.595 ZNF680
zinc finger protein 680
chr2_-_10505902 0.589 NM_002539
ODC1
ornithine decarboxylase 1
chr19_+_60168463 0.572 NM_001174081
NLRP2
NLR family, pyrin domain containing 2
chr2_+_5750229 0.569 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr10_-_92671005 0.568 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr17_-_26672757 0.564 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr9_+_138991835 0.560 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr2_-_152299229 0.560 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr12_+_52696908 0.550 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr1_+_154478574 0.542 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr1_+_149298774 0.538 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr2_-_10505724 0.537 ODC1
ornithine decarboxylase 1
chr7_+_152087753 0.537 NM_001040135
NM_020445
ACTR3B

ARP3 actin-related protein 3 homolog B (yeast)

chr2_+_108571209 0.533 LIMS1
LIM and senescent cell antigen-like domains 1
chr17_-_74487527 0.533 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr4_-_186970366 0.532 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr9_+_4669557 0.531 NM_017913
CDC37L1
cell division cycle 37 homolog (S. cerevisiae)-like 1
chr19_+_23091616 0.530 ZNF730
zinc finger protein 730
chr3_-_139376326 0.526 DBR1
debranching enzyme homolog 1 (S. cerevisiae)
chr17_-_3546236 0.526 NM_002561
NM_175080
NM_175081
P2RX5-TAX1BP3
P2RX5


P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5


chrX_+_30171768 0.515 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr7_-_63660889 0.511 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr12_+_55443358 0.510 NM_003725
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
chr9_-_129679760 0.506 NM_000476
AK1
adenylate kinase 1
chr1_+_208568218 0.501 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr7_+_129693938 0.500 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr15_+_97990705 0.498 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr6_-_46401363 0.495 NM_005822
RCAN2
regulator of calcineurin 2
chr6_-_152681171 0.482 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr13_-_45654327 0.467 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_56817568 0.464 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_-_27097782 0.453 ABI1
abl-interactor 1
chr10_-_69267774 0.447 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr6_-_116553918 0.444 NM_000493
COL10A1
collagen, type X, alpha 1
chr5_-_111119846 0.443 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr12_+_79634820 0.442 NM_005593
MYF5
myogenic factor 5
chr4_+_70896236 0.431 NM_001009181
NM_003154
STATH

statherin

chr17_-_64752550 0.428 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr1_-_16217025 0.424 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr14_-_101841222 0.422 NM_014226
RAGE
renal tumor antigen
chr19_-_58086410 0.420 NM_207333
ZNF320
zinc finger protein 320
chr13_-_45654296 0.419 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_+_7563763 0.415 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr3_+_69895651 0.410 NM_006722
MITF
microphthalmia-associated transcription factor
chr15_+_66695932 0.405 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr5_+_159368690 0.403 TTC1
tetratricopeptide repeat domain 1
chr4_+_169789327 0.402 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr1_-_201321711 0.399 MYOG
myogenin (myogenic factor 4)
chr6_+_12825818 0.395 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr12_-_6535481 0.389 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr2_-_200038055 0.385 NM_001172517
SATB2
SATB homeobox 2
chr7_+_93861808 0.383 NM_000089
COL1A2
collagen, type I, alpha 2
chr13_-_37070862 0.382 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr6_+_27885692 0.376 NM_003536
HIST1H3H
histone cluster 1, H3h
chr4_+_129950222 0.376 NM_024900
NM_199320
PHF17

PHD finger protein 17

chr5_+_159368721 0.373 TTC1
tetratricopeptide repeat domain 1
chr1_+_145892190 0.373 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr5_-_142045770 0.372 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr1_+_242283129 0.366 NM_006352
ZNF238
zinc finger protein 238
chr9_-_21218132 0.362 NM_021268
IFNA17
interferon, alpha 17
chr17_-_38385511 0.362 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr2_-_217268492 0.361 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr19_-_60360768 0.359 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr19_+_19872700 0.353 NM_031218
ZNF93
zinc finger protein 93
chr2_+_85619797 0.353 NM_005911
MAT2A
methionine adenosyltransferase II, alpha
chr13_+_51933228 0.350 CKAP2
cytoskeleton associated protein 2
chr20_-_33463194 0.349 NM_001184977
NM_018244
NM_199487
UQCC


ubiquinol-cytochrome c reductase complex chaperone


chr1_+_201364050 0.344 ADORA1
adenosine A1 receptor
chr1_+_13784553 0.342 NM_001006624
NM_001006625
PDPN

podoplanin

chr7_+_64476167 0.338 NM_007139
NM_152626
ZNF92

zinc finger protein 92

chr2_-_55053398 0.331


chr2_+_108571336 0.330 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_38746555 0.330 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr8_-_120033240 0.328 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr5_+_159368733 0.327 NM_003314
TTC1
tetratricopeptide repeat domain 1
chr5_-_58688428 0.325 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_65503011 0.323 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr16_+_6763810 0.323 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_+_170370290 0.321 SSB
Sjogren syndrome antigen B (autoantigen La)
chr2_+_172087102 0.321 NM_001127383
NM_024843
CYBRD1

cytochrome b reductase 1

chr11_-_14342627 0.320 NM_001177314
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr5_-_142057692 0.316 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr2_+_85619802 0.315 MAT2A
methionine adenosyltransferase II, alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.44 4.09e-06 GO:0030049 muscle filament sliding
6.44 4.09e-06 GO:0033275 actin-myosin filament sliding
6.27 6.37e-06 GO:0070252 actin-mediated cell contraction
3.12 6.74e-06 GO:0003012 muscle system process
4.98 8.88e-05 GO:0030048 actin filament-based movement
5.73 2.53e-04 GO:0006941 striated muscle contraction
2.53 2.56e-04 GO:0061061 muscle structure development
2.89 5.74e-04 GO:0006936 muscle contraction
2.81 6.52e-04 GO:0007517 muscle organ development
2.40 1.04e-03 GO:0030029 actin filament-based process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.34 1.09e-14 GO:0030016 myofibril
5.01 1.11e-13 GO:0043292 contractile fiber
5.19 2.41e-13 GO:0044449 contractile fiber part
5.54 6.63e-13 GO:0030017 sarcomere
5.03 2.25e-04 GO:0031674 I band
4.96 5.09e-03 GO:0030018 Z disc
11.34 5.73e-03 GO:0005861 troponin complex
1.32 6.76e-03 GO:0043228 non-membrane-bounded organelle
1.32 6.76e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.46 7.94e-03 GO:0005856 cytoskeleton
7.94 1.26e-02 GO:0031672 A band
3.32 1.77e-02 GO:0042383 sarcolemma
12.70 2.31e-02 GO:0031430 M band
2.02 2.43e-02 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.65 2.37e-03 GO:0008307 structural constituent of muscle
1.99 4.26e-02 GO:0003779 actin binding